Rick Simpson Oil (RSO) is a highly concentrated form of cannabis extract known for its high THC content and potential therapeutic benefits. RSO was developed by Rick Simpson, a Canadian medical cannabis advocate who used the extract to treat his skin cancer.
If you’ve been researching medical cannabis or exploring the different types of cannabis extractions, you’ve no doubt come across RSO.
While this extract is highly beneficial, though, it’s also the cause for some confusion: where is it legal? How does it differ from THC distillate? How do you take it?
In this article, we answer these questions and others about what RSO is.
What is RSO?
Rick Simpson Oil (RSO) is a cannabis extract that contains very high levels of THC alongside other compounds. It was first developed by (and is named for) Rick Simpson, a Canadian medical cannabis advocate who used the extract to treat his skin cancer, then later shared his story around the world.
Unlike some cannabis concentrates, RSO is a full-spectrum extract, meaning it retains all the cannabinoids, terpenes, and other compounds naturally found in cannabis, maximizing the potential therapeutic effects you receive.
Due to its high THC concentration, RSO is known for its potent psychoactive effects and is primarily used for medicinal purposes, most notably cancer treatment and symptom relief.
Benefits of RSO: What Is It Used For?
Research suggests RSO has beneficial effects in a variety of use cases:
- Cancer: Preliminary research has indicated that cannabinoids, particularly THC and CBD, may have potential anti-cancer properties, including the ability to induce apoptosis (programmed cell death) in cancer cells and inhibit tumor growth in animal models [1].
- Cancer Symptom Management: Preliminary research suggests that THC, CBD, and other cannabinoids found in RSO may have therapeutic benefits for cancer symptoms such as pain, nausea, and appetite loss [2].
- Pain and Inflammation: Research suggests THC and other cannabinoids may have analgesic (pain-reducing) and anti-inflammatory properties [3,4]. Cannabinoids may work by interacting with your body’s endocannabinoid system, which regulates pain perception.
- Neurological Conditions: Preliminary research suggests that THC, CBD, and the other cannabinoids found in RSO may have neuroprotective properties, potentially benefiting people with neurological conditions [5].
- Anxiety and Mood Disorders: RSO, which is high in THC and CBD, may have beneficial properties for mood disorders in lower doses (higher doses of THC may exacerbate anxiety). Preliminary research has found that THC and CBD have potential therapeutic benefits in these sorts of use cases [6,7].
- Appetite Stimulation: Research suggests that THC may have appetite-stimulating properties. THC has specifically been researched as an appetite stimulant in cancer patients, and many studies have shown positive results [8]. Given RSO’s high THC content, it may offer these therapeutic benefits.
- Sleep: RSO is high in THC and CBD, which have sedative and relaxing properties, respectively. THC and CBD have both been researched for their potential therapeutic benefits for sleep disorders [9,10].
- Antibacterial Properties: Research suggests cannabinoids may possess antibacterial properties. Cannabinoids have been studied for their effect on antibiotic-resistant strains like MRSA, in particular [11]. RSO is rich in a variety of cannabinoids, meaning it may offer these benefits.
- Seizure Management: Cannabinoids, particularly CBD, have been investigated for their anticonvulsant properties. Given that RSO is a full-spectrum extract containing CBD and a variety of other beneficial cannabinoids, it might have these properties [12].
How RSO Works in the Body
RSO renders its therapeutic benefits by interacting with the endocannabinoid system (ECS), a complex receptor system in your body that regulates vital functions like mood, pain, sleep, inflammation, and immune response.
The high THC content in RSO binds to CB1 receptors in the brain and central nervous system, creating psychoactive effects and influencing pain perception, appetite, and mood.
Meanwhile, the CBD and other cannabinoids in RSO interact with CB2 receptors, which are more prevalent in the immune system and peripheral tissues.
This full-spectrum interaction (commonly called the entourage effect) allows RSO to comprehensively enhance the function of your ECS, thereby promoting better states of physical and mental health.
RSO’s concentrated nature allows it to deliver stronger effects than other cannabis products, which is why it’s often used for conditions like cancer, chronic pain, and neurological disorders.
The mechanisms by which RSO works in the ECS are numerous. RSO’s benefits for cancer may be due to the fact that the ECS regulates cell proliferation, apoptosis (programmed cell death), and other processes that influence the presence of cancer cells.
More research is needed on how RSO renders its benefits, but based on what we know, its interaction with the ECS plays a large part in its therapeutic potential.
RSO Side Effects & Safety Precautions
While RSO is immensely beneficial, it also has the potential to cause side effects – especially due to its high THC levels and psychoactive effects.
Potential side effects of RSO include:
- Drowsiness
- Dry mouth
- Red eyes
- Increased appetite
- Slowed reaction time
- Anxiety
- Dizziness
Because of these side effects, we recommend you start with a small dose of RSO and gradually work your way up. The Rick Simpson protocol calls for a drop of oil half the size of a grain of rice, or about 30mg, then recommends you increase this dose over time as your body acclimates to the effects.
For more, see the Rick Simpson protocol and our RSO dosage guide.
RSO vs. THC Distillate vs. CBD
Wondering how RSO compares to THC distillate and cannabidiol (CBD)?
Here’s a breakdown of how these cannabis extracts measure up to each other:
| Dimension | RSO | THC Distillate | CBD |
| What They Are | Full-spectrum cannabis extract containing all plant compounds | Refined cannabis extract containing nearly pure tetrahydrocannabinol (THC) | Cannabis extract containing pure cannabidiol (CBD) or CBD with other cannabinoids and terpenes |
| Cannabinoid/Terpene Content | High in THC, includes full range of cannabinoids and terpenes | High THC with minimal or no secondary cannabinoid or terpene content | High in CBD; may be full-spectrum, broad-spectrum, or isolate |
| Psychoactive Effects | Yes – very potent due to high THC content | Yes – very potent due to nearly pure THC content | No – CBD is non-psychoactive |
| Extraction Method | Solvent-based (ethanol or isopropyl alcohol) | Solvent extraction followed by distillation | CO₂ or ethanol extraction |
| Benefits and Uses | Cancer treatment and symptom support, pain relief, neurological disorders, sleep | Pain relief, sleep, recreation | Anxiety, pain relief, seizures, general wellness support |
| Legality and Availability | Legal in cannabis-legal states or online through RickSimpsonOil.com | Legal in cannabis-legal states; widely available if hemp-derived and under 0.3% THC (U.S. federal law) | Widely available if hemp-derived and under 0.3% THC (U.S. federal law) |
How to Use RSO
RSO can be taken in a variety of different ways – here’s a bit about the main types of products:
- RSO Syringes: RSO syringes contain full-spectrum Rick Simpson Oil in its purest, most concentrated form. They allow for precise dosing and versatile use, including oral ingestion, sublingual absorption, topical application, and infusion into food. Because syringes are so potent, people typically start with a small dose and gradually increase as needed.
- RSO Tinctures: RSO tinctures are a liquid form of Rick Simpson Oil mixed with a carrier oil, making them easier to dose and absorb. They are typically taken sublingually (under the tongue) for faster effects or mixed into food and beverages for a more gradual onset. RSO tinctures offer a discreet and convenient way to experience full-spectrum cannabis benefits.
- RSO Gummies: RSO gummies are infused with full-spectrum Rick Simpson Oil, providing a flavorful and easy way to consume RSO. Each gummy contains a pre-measured dose, allowing for controlled intake and a more enjoyable alternative to raw RSO. Gummies take longer to kick in due to digestion but offer long-lasting effects.
- RSO Suppositories: RSO suppositories are designed for rectal or vaginal use, allowing for rapid absorption of cannabinoids without the psychoactive intensity of oral ingestion. This method bypasses digestion, delivering high bioavailability and targeted therapeutic effects. RSO suppositories are commonly used for pain relief, cancer symptom management, and gastrointestinal conditions.
- RSO Capsules: RSO capsules offer a pre-measured, tasteless way to consume Rick Simpson Oil without having to deal with its thick consistency. You can swallow capsules like a regular supplement, and they’ll provide slow-release effects as you digest them. They are ideal for users seeking precise dosing and long-lasting therapeutic benefits.
- RSO Joints: RSO joints are pre-rolled cannabis joints infused with Rick Simpson Oil for enhanced potency and full-spectrum effects. They offer a stronger experience compared to regular pre-rolls due to the addition of concentrated RSO. This method provides fast-acting effects and is popular among those seeking immediate relief and a more intense cannabis experience.
Is RSO Legal?
RSO is a cannabis product (as opposed to a hemp product), and is therefore only legal in US states where cannabis is regulated. You can purchase it from a licensed dispensary in some states, while in others, you’ll need a medical marijauna card and will need to get your RSO from a specialized vendor.
However, there is one exception: the Official Rick Simpson Oil Website. We operate under special licensing and regulatory compliance that allows us to legally produce, sell, and ship our products throughout the United States. You can buy RSO online from our website, and we’ll ship it directly to your doorstep.
In addition to U.S. domestic shipping, we also serve select international destinations where regulations permit. This ensures we can help people everywhere get access to safe, effective, lab-tested RSO.
Conclusion: Is RSO Right For You?
If you’re using cannabis for medical purposes and need powerful relief, RSO may be the right choice for you.
It’s the strongest cannabis extract out there, and it renders the full-spectrum benefits of the cannabis plant in a way that allows you to receive the maximum possible benefit.
Read About the Best RSO Products
What is RSO: Frequently Asked Questions
Here are some questions our customers frequently ask us about RSO:
Will RSO Get Me High?
Yes, RSO will get you high because it contains a high concentration of THC, the primary psychoactive compound in cannabis. The intensity can vary depending on your dosage and tolerance.
What Does RSO Do?
RSO works by interacting with your body’s endocannabinoid system to support functions like cancer cell regulation, pain relief, sleep, appetite, and inflammation.
Is RSO More Potent Than Edibles?
RSO is often more potent than regular edibles because it’s a full-spectrum, concentrated cannabis oil. It contains a wider range of cannabinoids and plant compounds, offering a stronger and more therapeutic effect.
What is The Difference Between CBD and RSO?
The difference between CBD and RSO is that CBD is a non-psychoactive cannabinoid, while RSO is a high-THC full-spectrum extract. RSO offers psychoactive effects and is typically used for more intense therapeutic needs.
What Are RSO Syringes?
RSO syringes are pre-filled applicators that contain Rick Simpson Oil in its purest form. They allow for precise dosing and can be used orally, sublingually, topically, or mixed with food.
What Are RSO Gummies?
RSO gummies are edible products infused with Rick Simpson Oil, offering a great-tasting and discreet to consume cannabis. Each gummy contains a measured dose of full-spectrum cannabis extract.
What Are RSO Edibles?
RSO edibles include gummies, chocolates, and other ingestible products made with Rick Simpson Oil. They provide long-lasting relief and are easy to dose for therapeutic or recreational use.
What is Indica RSO?
Indica RSO is Rick Simpson Oil made from indica-dominant cannabis strains. It tends to have relaxing, sedative effects and is best for sleep, stress, or pain relief.
