If you’re researching the best RSO products for therapeutic or recreational use, you might be feeling a little overwhelmed from all the available options.
There’s a lot to consider when deciding which product you should buy – potency, price, brand reputation, and whether you can buy a product online, to name a few relevant factors.
So to help you find the best Rick Simpson Oil product, we reviewed dozens of products. In this article, we’re presenting you with our top nine.
What is RSO?
Rick Simpson Oil (RSO) is a highly concentrated form of cannabis extract known for its high THC content and potential therapeutic benefits. RSO was developed by Rick Simpson, a Canadian medical cannabis advocate who used the extract to treat his skin cancer.
Unlike some cannabis concentrates, RSO is a full-spectrum extract, meaning it retains all the naturally-occurring cannabinoids, terpenes, and plant compounds, maximizing the potential therapeutic effects you receive.
Due to its high THC concentration, RSO is known for its potent psychoactive effects and is primarily used for medicinal purposes.
A Quick Look at the Best RSO Products in 2025
Best RSO Oil: RickSimpsonOil 10g Syringe
Best RSO Capsules: MÜV RSO Capsules
Best RSO Gummies: RickSimpsonOil Tangerine RSO Gummies
Best RSO Tincture: Trulieve Mixed Berry RSO Tincture 1:20
Best RSO Suppositories: RickSimpsonOil RSO Suppositories
Best RSO for Pain: Rise RSO Cream
Best RSO for Sleep: Double Delicious CBN RSO Syringe
Best RSO for Relaxation: Lazarus Naturals CBD RSO Syringe
Best RSO for Dogs: RickSimpsonOil Original RSO Tincture
How We Chose the Best RSO Products
To recommend only the highest-quality RSO products, we’ve only included products that meet these standards:
- Made by a company that has its products 3rd-party lab tested and provides proof
- Made by a company that discloses the source of its cannabis
- Passes tests for contaminants such as pesticides, heavy metals, and molds
In conducting our review, we also accounted for things like:
- The user reviews of each product
- The ingredients in each product
- The available of each product
We’ve aimed to include a variety of RSO products, rather than just comparing a bunch of similar items. To this end, our review includes the best RSO product of each type as well as the best RSO products for specific use cases.
Best RSO Products in 2025
Without further ado, here are the 9 best RSO products in 2025:
1. Best RSO Oil: RickSimpsonOil 10g Pure RSO Syringe
As the Official Rick Simpson Oil website, our pure RSO syringes are the gold standard for patients seeking a powerful, full-spectrum cannabis extract for therapeutic use, with the 10g syringe being the go-to for many people.
These syringes contain activated cannabinoids, flavonoids, terpenes, and other plant compounds in a thick, concentrated oil designed for oral or topical use.
Ideal if you’re following the original RSO protocol, our 10g syringes allow for precision dosing and extended use.
Price: $360.00
Potency: 10g pure RSO
Size: 1 10g syringe (sold individually)
2. Best RSO Capsules: MÜV RSO Capsules
MÜV RSO Capsules provide a convenient, consistent RSO delivery method for those needing full-spectrum cannabis effects.
Each capsule contains 25mg of RSO and is powered by MÜV’s EnCaps™ technology, which enhances absorption and leads to faster onset compared to RSO edibles.
These capsules are formulated with the full profile of the cannabis plant, including cannabinoids, terpenes, flavonoids, and natural lipids, delivering whole-plant synergy in each dose.
Price: $80.00
Potency: 25mg RSO per capsule
Size: 30 capsules per bottle
3. Best RSO Gummies: RickSimpsonOil Tangerine RSO Gummies
Our tangerine RSO gummies deliver potent, full-spectrum cannabis extract alongside delicious flavors.
Each gummy contains 50mg of high-THC RSO, delivering a powerful dose in a tasty, citrus-flavored package.
Made with real fruit and 100% organic ingredients, our gummies are perfect if you prefer an edible format (due to the strong taste of RSO) but still need serious effects.
Price: $69.00
Potency: 50mg RSO per gummy
Size: 10 gummies per pouch
4. Best RSO Tincture: Trulieve Mixed Berry RSO Tincture
Trulieve Mixed Berry RSO Tincture features THC and CBD in a 20:1 ratio and a light, fruity flavor.
Trulieve’s formulation is perfect if you’re looking for powerful relief from cannabis without as strong of a high. The CBD helps temper the more extreme aspects of the THC high, enabling you to instead experience only what you need: relief.
Available in indica, sativa, or hybrid variants, this tincture is meant for sublingual use, allowing for faster onset and easier dose control compared to edibles or capsules.
Price: $100.00
Potency: 1200mg THC:CBD per bottle (20:1 ratio)
Size: 1 oz (30 ml)
Shop Trulieve Mixed Berry RSO Tincture
5. Best RSO Suppositories: RickSimpsonOil RSO Suppositories
Our RSO suppositories provide an alternative delivery method if you need fast-acting relief without the psychoactive intensity from orally delivered THC.
These 1g RSO suppositories are designed for rectal or vaginal use and deliver RSO through internal membranes, bypassing your digestive system and thereby allowing quicker cannabinoid absorption into the bloodstream.
Each dose delivers pure, full-spectrum RSO directly to the body, allowing for strong therapeutic benefits with only a mild head sensation.
Price: $25.00
Potency: 1g RSO per suppository
Size: 1 suppository (sold individually)
6. Best RSO for Pain: Rise RSO Cream
Rise’s RSO cream is a topical formula designed for people using RSO for pain or cancer relief and who prefer not to ingest cannabis.
This 3 oz cream combines 3000mg of full-spectrum RSO with a clean, plant-based cream that’s fast-absorbing, fragrance-free, and non-greasy.
You apply it directly where it hurts, and it works – no high, no taste, just targeted relief.
The downside is that you won’t get full-body effects, since topicals don’t deliver RSO to the bloodstream. But for localized relief on specific areas of the body, Rise’s cream is the best option out there.
Price: $60.00
Potency: 3000mg total cannabinoids
Size: 3 oz of cream per tube
7. Best RSO for Sleep: Double Delicious CBN RSO Syringe
Double Delicious’s high-CBN RSO oil is crafted with sleep in mind, blending traditional RSO’s therapeutic properties with elevated levels of CBN – a cannabinoid renowned for its sedative effects.
This formulation is ideal if you’re using RSO for sleep support or nighttime stress and anxiety. It delivers a heavy, full-spectrum effect that eases both the body and mind into deep relaxation.
A major benefit of RSO, especially when combined with CBN, is that it can promote long, uninterrupted rest without the next-day grogginess often associated with pharmaceutical sleep aids. Double Delicious’ RSO syringes deliver this beneficial extract in a method that allows for flexible consumption.
Price: $18.00
Potency: 1g high-CBN RSO (10:1 THC:CBN)
Size: 1 1g syringe (sold individually)
Shop Double Delicious CBN RSO Syringe
8. Best RSO for Relaxation: Lazarus Naturals CBD RSO Syringe
Lazarus Naturals’ CBD RSO syringe delivers this beneficial cannabis extract alongside elevated amounts of CBD, resulting in soothing, mildly psychoactive effects.
Designed to promote relaxation, reduce stress, and support overall wellness, these syringes contain either 400mg or 1000mg CBD-dominant RSO, which includes THC, CBN, CBG and CBC, plus terpenes
While not as strong as high-THC RSO, the pure oil in these syringes is perfect if you’re a newer therapeutic user who isn’t comfortable taking large amounts of THC.
Price: $32.00 (2.5 ml) or $100.00 (10 ml)
Potency: 1000mg or 4000mg CBD-rich RSO
Size: 1 2.5 ml or 10 ml syringe (sold individually)
Shop Lazarus Naturals CBD RSO Syringe
9. Best RSO for Dogs: RickSimpsonOil Original RSO Tincture
The benefits of RSO don’t just apply to humans: they also apply to dogs, cats, and other pets. Many of our customers come to us looking to use RSO to help their pets with cancer or pain, and our original RSO tincture is always our first recommendation.
This 1000mg RSO tincture combines pure RSO with a carrier oil to allow for easy dosing. You can give it directly to your dog, or you can mix it in with their food.
Because RSO tinctures are less potent than pure RSO, our tincture is a great way to give your dog the benefits of RSO without accidentally giving them too much.
Price: $100.00
Potency: 1000mg RSO per bottle
Size: 1 oz (30 ml)
Benefits of RSO
Research suggests that THC and CBD, both of which occur abundantly in RSO, may have therapeutic benefits in a variety of areas:
- Cancer: Preliminary research has indicated that cannabinoids, particularly THC and CBD, may have potential anti-cancer properties, including the ability to induce apoptosis (programmed cell death) in cancer cells and inhibit tumor growth in animal models [1].
- Cancer Symptom Management: Preliminary research suggests that THC, CBD, and other cannabinoids found in RSO may have therapeutic benefits for cancer symptoms such as pain, nausea, and appetite loss [2].
- Pain and Inflammation: Research suggests THC and other cannabinoids may have analgesic (pain-reducing) and anti-inflammatory properties [3,4]. Cannabinoids may work by interacting with your body’s endocannabinoid system, which regulates pain perception.
- Neurological Conditions: Preliminary research suggests that THC, CBD, and the other cannabinoids found in RSO may have neuroprotective properties, potentially benefiting people with neurological conditions [5].
- Anxiety and Mood Disorders: RSO, which is high in THC and CBD, may have beneficial properties for mood disorders in lower doses (higher doses of THC may exacerbate anxiety). Preliminary research has found that THC and CBD have potential therapeutic benefits in these sorts of use cases [6,7].
- Appetite Stimulation: Research suggests that THC may have appetite-stimulating properties. THC has specifically been researched as an appetite stimulant in cancer patients, and many studies have shown positive results [8]. Given RSO’s high THC content, it may offer these therapeutic benefits.
- Sleep: RSO is high in THC and CBD, which have sedative and relaxing properties, respectively. THC and CBD have both been researched for their potential therapeutic benefits for sleep disorders [9,10].
- Antibacterial Properties: Research suggests cannabinoids may possess antibacterial properties. Cannabinoids have been studied for their effect on antibiotic-resistant strains like MRSA, in particular [11]. RSO is rich in a variety of cannabinoids, meaning it may offer these benefits.
- Seizure Management: Cannabinoids, particularly CBD, have been investigated for their anticonvulsant properties. Given that RSO is a full-spectrum extract containing CBD and a variety of other beneficial cannabinoids, it might have these properties [12].
How to Use RSO
No matter which RSO product or delivery method you choose, following these directions will help you see the best therapeutic or recreational results:
Dosage
We recommend starting with very small doses of RSO and gradually increasing until you achieve your desired result.
Start by taking a small dose of RSO oil about half the size of a short rice grain (or an equivalent if using a product other than pure RSO oil from an oral syringe).
Take this dose once a day and slowly increase it until you get your desired results.
If you’re using RSO for cancer, see our RSO protocol. Otherwise, see our RSO dosage guide for more information.
Effect Onset
In an edible form (e.g. oral syringe, gummies, etc.), RSO will kick in within 45 minutes to 1 hour.
If you’re using an RSO tincture or other sublingual method, RSO will kick in within 10 to 15 minutes.
Based on these onset ranges, time your RSO doses so you get the effects you want, when you want.
Conclusion: What’s the Best RSO in 2025?
Ultimately, there is no “best” RSO product – only the best RSO product for your specific needs. We hoped the recommendations we provided help you find something that works for you.
However, there are some general rules of thumb to keep in mind.
Heavy-duty therapeutic uses (e.g. cancer or chronic pain) require very potent RSO products (e.g. oral syringes with pure RSO oil).
Products with high levels of CBN are better for sleep. Products with high levels of CBD are best for more balanced mental effects.
Apart from these suggestions, though, using your best judgement will help you find the best RSO; look for 3rd-party lab tested products with positive user reviews from reputable brands with a history of customer satisfaction.
Best RSO: Frequently Asked Questions
Here are some questions our customers frequently ask us about the best RSO products:
What Is the Best RSO Brand?
While there’s no definitive “best” RSO brand, the Official Rick Simpson Oil Website is one of the most reliable and reputable RSO providers. Our wide selection of RSO products are formulated for therapeutic use, 3rd-party lab tested, and made from premium cannabis. One key benefit of shopping with us is that you can buy online and have your products shipped to your doorstep all through America, as well as in select international countries.
What Is the Best Carrier Oil for RSO?
MCT oil is widely considered the best carrier for RSO because it’s easily absorbed and increases bioavailability, though olive and hemp seed oil are also solid options.
What Is Better Than RSO?
While some people prefer solventless concentrates like full-spectrum rosin for their purity, RSO is uniquely valued for its whole-plant, high-THC composition – “better” depends on your goals (e.g. clean dabbing vs. long-term therapeutic use).
Is Indica RSO Better Than Sativa RSO?
Indica-based RSO is generally preferred for nighttime use due to its sedative, pain-relieving effects, while sativa RSO may offer more energizing, cerebral effects – the type of RSO that’s best depends entirely on your needs and time of use.
Sources
[1] Guggisberg, J., Schumacher, M., Gilmore, G., & Zylla, D. M. (2022). Cannabis as an Anticancer Agent: A Review of Clinical Data and Assessment of Case Reports. Cannabis and cannabinoid research, 7(1), 24–33. https://doi.org/10.1089/can.2021.0045
[2] Brooke, W. et al., Cannabis Use in Patients With Cancer: A Clinical Review. JCO Oncol Pract 18, 743-749(2022). DOI:10.1200/OP.22.00080
[3] Weizman, L., Dayan, L., Brill, S., Nahman-Averbuch, H., Hendler, T., Jacob, G., & Sharon, H. (2018). Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity. Neurology, 91(14), e1285–e1294. https://doi.org/10.1212/WNL.0000000000006293
[4] Anil, S. M., Peeri, H., & Koltai, H. (2022). Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action. Frontiers in pharmacology, 13, 908198. https://doi.org/10.3389/fphar.2022.908198
[5] Prakash, S., & Carter, W. G. (2021). The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies. Brain sciences, 11(12), 1573. https://doi.org/10.3390/brainsci11121573
[6] Lichenstein S. D. (2022). THC, CBD, and Anxiety: A review of recent findings on the anxiolytic and anxiogenic effects of cannabis’ primary cannabinoids. Current addiction reports, 9(4), 473–485. https://doi.org/10.1007/s40429-022-00450-7
[7] Wright, M., Di Ciano, P., & Brands, B. (2020). Use of Cannabidiol for the Treatment of Anxiety: A Short Synthesis of Pre-Clinical and Clinical Evidence. Cannabis and cannabinoid research, 5(3), 191–196. https://doi.org/10.1089/can.2019.0052
[8] Nelson, K., Walsh, D., Deeter, P., & Sheehan, F. (1994). A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia. Journal of palliative care, 10(1), 14–18.
[9] Ried, K., Tamanna, T., Matthews, S., & Sali, A. (2023). Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study. Journal of sleep research, 32(3), e13793. https://doi.org/10.1111/jsr.13793
[10] Kisiolek, J. N., Flores, V. A., Ramani, A., Butler, B., Haughian, J. M., & Stewart, L. K. (2023). Eight Weeks of Daily Cannabidiol Supplementation Improves Sleep Quality and Immune Cell Cytotoxicity. Nutrients, 15(19), 4173. https://doi.org/10.3390/nu15194173
[11] Schofs, L., Sparo, M. D., & Sánchez Bruni, S. F. (2021). The antimicrobial effect behind Cannabis sativa. Pharmacology research & perspectives, 9(2), e00761. https://doi.org/10.1002/prp2.761
[12] Silvestro, S., Mammana, S., Cavalli, E., Bramanti, P., & Mazzon, E. (2019). Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials. Molecules (Basel, Switzerland), 24(8), 1459. https://doi.org/10.3390/molecules24081459
